The EBOVAC2 Consortium brings together Janssen Vaccines & Prevention B.V as Project Leader and Inserm as Coordinator with its leading expertise in the coordination of large clinical trials in Europe and Africa (ISO 9001:2008 certification), coordination of vaccine and immune intervention trials (especially in HIV) and Immune monitoring in HIV infections and other diseases as well as Inserm’s key infrastructures notably EUCLID (Trials Services Platform & Development) and the Jean Mérieux BSL4 Laboratory possessing the highest level of international biological safety standards to ensure that the heterologous two-dose vaccination regimen can demonstrate efficacy in non-human primates (NHPs).
The London School of Hygiene & Tropical Medicine (LSHTM) has played a key role in many vaccine trials conducted in developing countries ranging from Phase 1 to Phase 2b large scale safety and immunogenicity study. LSHTM is well qualified to support many aspects of multidisciplinary trials of Ebola vaccines. The University of Oxford group has been running vaccine clinical trials with children and adults in the UK and will bring its expertise to EBOVAC2 for Phase 2 studies.
EBOVAC2’s African partner, the CENTRE MURAZ, will ensure strong African involvement in the clinical trials and associated activities, notably communication and capacity building. Inserm Transfert, with its dedicated and professional European Project Management and IPR management teams, will ensure that EBOVAC2 produces high-quality results, adheres to all contractual expectations and communicates efficiently to all stakeholders.