EBOVAC2 is organised into 6 workpackages (WP), or groups of activities, in order to reach its objectives.

WP1 will oversee the activities of all work packages and interact with the overall EBOLA+ programme governance. WP2 will conduct the clinical trials, enroll volunteers, collect blood samples, and record clinical trial data. The collected blood samples will be sent to the laboratories participating in WP3 who will be in charge of the immunogenicity measurements of the trial samples. WP4 will be in close interaction with WP2 and WP3 to translate results from clinical to NHP research and vice versa. WP5 will manage the upload of EBOVAC2 data into the data repository. WP6 will be in charge of disseminating the information relative to the overall project (WP1) as well as milestones and results of each work package.


WP1: Project coordination and management

The objectives of this WP are three-fold:

  • At the strategic level, to ensure that the project reaches its objectives and expected impacts;
  • At the managerial level, to put in place the procedures and tools needed to ensure that the project progresses in conformity with the work plan and produces timely and quality results as well as overseeing conformity of all activities to IMI JU rules and the Consortium agreement;

At the administrative level, to organise project meetings, prepare project reports, manage the project budget and payments.

Leader: Inserm

WP2: Clinical core

This WP aims to confirm the robustness of safety and immunogenicity of the Ad26.ZEBOV/MVA-BN-Filo heterologous prime boost vaccine regimen obtained in phase 1 trials through the conduct of phase 2 trials in European and African populations.

Leader: Inserm/Janssen

WP3: Immune monitoring (Phase II trial)

The objectives of this WP are to analyse the immunogenicity of the Ad26.ZEBOV/MVA-BN-Filo heterologous prime boost vaccine regimen in phase 2 trials conducted in European and African populations through:

  • Evaluation of the immune response to the prime/boost based on protocol-defined endpoints (core immuno assessment including T cell and antibody responses);
  • Extensive characterization of the immune response to the vaccine regimen (cellular functionality, neutralisation of living virus);
  • Description of the immune signature and to better understand the mechanism of the vaccine regimens effect through gene expression monitoring;

Integrative statistical analysis of the gene expression and functional assays to understand and predict the effect of the vaccine regimen on the immune system.

Leader: Inserm

WP4: Translational studies to link vaccine elicited immune responses in humans to protection from Ebola in vaccinated non-human primates (NHP).

The objective of this WP is to carry out translational studies to link vaccine elicited immune responses in humans to protection from Ebola in vaccinated non-human primates.

Leader: Inserm

WP5: Data management and integration

The primary objective of the data management and integration work package is to load EBOVAC2 data to the INFOCENTRE (joint Ebola+ program data collection platform) and conduct statistical analysis on the data available. This WP will be carried out in compliance with the consortium Information Governance Model and project agreement.

Leader: Janssen

WP6: Communication and Capacity Building

The objectives of this WP are to develop and implement a communication plan involving all relevant stakeholders and beneficiaries of EBOVAC2. In addition, best practices and procedures for performing clinical trials will be developed and medical and non-medical laboratory staff will be trained on prime boost vaccine management.

Leader: Inserm Transfert


  • Data to demonstrate the safety, immunogenicity and, potentially, the efficacy of the prime-boost vaccine regimen in prevent Ebola virus disease
  • Reduced disease burden: if proved effective the vaccine will also potentially contribute to preventing future epidemics, saving lives and reducing suffering and damage to health systems and wider society in affected countries
  • Capacity development in affected countries to ensure preparedness for future outbreaks


  • 24 September 2018

    The 6th edition of the newsletter is available here. This issue contains an interview with Inserm's BSL-4 Laboratory director, Dr. Hervé Raoul. 

  • 24 September 2018

    The 5th EBOVAC2 newsletter March 2018 is available here. This issue includes an article on the training course conducted in Burkina Faso in January 2018.

  • 17 January 2018

    Clinical Trial Training - Bobo Dioulasso, BURKINA FASO, 23-26 January, 2018. For more information

  • 02 January 2018

    The 4th edition of our EBOVAC2 newlsetter was released on the 21st of December 2017.

  • 27 October 2017

    The 3rd EBOVAC2 Newsletter is now available here. Our October 2017 issue includes an interview with Dr Houreratou Barry, PI of the Centre Muraz site.

  • 12 September 2017

    The 3rd EBOVAC1/2 Annual meeting will be held in Amsteram, the Netherlands 8-10 January 2018. Participants include consortium members and representatives of sites where the project clinical trials are being carried out.

More news
  • Ebola: background

    What is Ebola?

  • Phase 2 trials

    Find out more about EBOVAC2 trials

  • Work programme

    EBOVAC2 is organised into 6 workpackages (WP)

  • Ebola+ programme

    Contributes to efforts to tackle a wide range of challenges in Ebola research