The EBOVAC2 project is one of 8 projects funded under IMI Ebola+ programme that was launched in response to the Ebola virus disease outbreak. The project aims to assess the safety and efficacy of a novel prime boost preventive vaccine regimen against Ebola Virus Disease (EVD).

To expedite the development of the vaccine regimen, Phase 2 trials and a Phase 2B study will be carried out in parallel and therefore coordinated by two separate teams within EBOVAC1 (Phase 1 and Phase 2B large scale safety and immunogenicity study) and EBOVAC2 (Phase 2 trial) projects.

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Between them, the EBOVAC projects will assess, through phase I and phase 2 trials in Europe and Africa, as well as a Phase 2B large scale safety and immunogenicity study, the safety and tolerability of the vaccine regimen in response to the urgent public health need raised by the Ebola epidemic.

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News

  • 15 May 2017

    Based on final Phase 1 data published in JAMA: The Journal of the American Medical Association, the prime-boost Ebola vaccine regimen induced an antibody response that persisted in 100 percent of healthy volunteers to at least 1 year following vaccination. The results are from the EBOVAC1 study EBL1001 conducted by the Oxford Vaccine Group in the UK.

  • 15 May 2017

    Victoria Derbyshire reporter Catrin Nye went to visit the Oxford Vaccine Group looking for volunteers who participated in the EBL2001 study. Prof. Andrew Pollard (Professor of Paediatric Infection and Immunity and Oxford Vaccine Group PI for EBOVAC1 and EBOVAC2 ) and study volunteers were interviewed.Watch here : http://www.bbc.co.uk/news/uk-39202974

  • 13 November 2016

    The joint EBOVAC1 and EBOVAC2 annual meeting took place in Windsor, UK from 14-16 November 2016.

  • 22 April 2016

    EBOVAC1 has published their first report on Phase 1 data in the April 19th 2016 issue of JAMA

    Press release and more information

  • 04 April 2016

    The first subject was vaccinated on 30 March 2016 at the University of Nairobi, Kenya

  • 29 March 2016

    The 1st EBOVAC2 Newsletter is available!

More news
  • Ebola: background

    What is Ebola?

  • Phase 2 trials

    Find out more about EBOVAC2 trials

  • Work programme

    EBOVAC2 is organised into 6 workpackages (WP)

  • Ebola+ programme

    Contributes to efforts to tackle a wide range of challenges in Ebola research

ebovac2 in numbers

ebovac2 in numbers
  • 6 ORGANISATIONS

    4 institutes, 1 Industrial partner,1 private company
    in charge of Management

  • 3 EUROPEAN UNION MEMBER

    states involved

  • BUDGET

    €22,790,820 (IMI JU funding);
    EFPIA contribution: €15.1 million

  • 3 YEAR-DURATION

    1st December 2014 – 30 November 2017

ebovac1 trials

  • Phase 1

    Trial countries: UK and selected African countries

  • Large-scale efficacy study or expanded safety and immunogenicity study in Sierra Leone

    More information on ebovac1 trials coming soon

This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 115861.
This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA